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Assess and discuss if there is a difference in the mean baseline LDL between the group assigned to placebo and statin group BEFORE they are treated with corresponding treatment.

A Brief Synopsis of a Study

A group of physicians published the results of a study (Shepherd et al., 1995)* investigating the effect of statins in men (= 6595), 45 to 64 years of age, with high cholesterol. Their baseline low-density lipoprotein (LDL) levels were measured (in milligram/decilitre) before they were randomly assigned to either the statin group or the placebo group. After an average of five-year follow-up with the corresponding treatments, their LDL levels were measured again. A simulated subset of the original study (= 100, equally divided to each group, i.e., 50 in each group) was sampled and entered as follows in SPSS.

Ø Baseline LDL (Baseline): low-density lipoprotein measurement (LDL, in milligram/decilitre).

Ø LDL measured after five years of follow-up with respect to the group assignment (Followup): low-density lipoprotein measurement (LDL, in milligram/decilitre).

Ø Coding variable (Group): The value of 1 represents placebo group whereas the value of 2 represents the statin group.

 

The Objectives

The main objective of your poster is to (1) conduct appropriate statistical analyses for the following objectives and (2) provide succinct and concise summary of the results. You should note that making a poster can be quite different from writing a full report as a poster is targeting the audiences who will interact with you, a presenter, face-to-face as opposed to readers. As such, important information should be delivered through effective visualisation, which should be your main focus in the making of poster. For that matter, the total number of words will be limited to 750 for this poster. In addition to conducting the right analyses and understanding the results, you need to think about the ways how to deliver what you did and found in mosteconomical and effective way.

For all the objectives, you are required to use approximately 50% of randomly sampled data with Mersenne Twister algorithm using your student ID as a random seed. Please see the attached appendix how to do this. Depending upon the sampled data, you might have to choose a non-parametric alternative to the parametric counterpart. Again, the instructions to run each non-parametric test will be found in the appendices.

Analysis Objective 1

Assess and discuss if there is a difference in the mean baseline LDL between the group assigned to placebo and statin group BEFORE they are treated with corresponding treatment.

Analysis Objective 2

Analyse and discuss if there is an evidence of difference in the mean LDL of the group treated with placebo BEFORE AND AFTER they are treated.

Analysis Objective 3

Perform and discuss if there is an evidence of difference in the mean LDL of the group treated with statin BEFORE AND AFTER they are treated?

Analysis Objective 4

Evaluate and discuss if there is an evidence of difference in their mean treated LDL between the groups treated with placebo and statin AFTER they are treated for five years. Skills for Professional Practice for Bioscience 2 (MMC923627) EDA Coursework (BIO)

MMC923627 EDA CW Diet 1 (BIO) page 3 of 4

 

Study Data

The study data are available from the GCULearn module site. They are provided in a SPSS data file called SPPB2A18posterDataDiet1.sav. Store a copy of this file on a backup storage device (USB flash drive) and/or your own University workspace (H: drive) and/or PC/Laptop hard drive.

*The Original Study

The West of Scotland Coronary Prevention Study Group (1995). Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. The New England Journal of Medicine, 20(16):1301-1307. Skills for Professional Practice for Bioscience 2 (MMC923627) EDA 


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