Define synergism, antagonism and indifference in anti-bacterial chemotherapy with specific case examples
You must choose ONLY ONEquestion out of THREE
Each question is worth 100 marks.
In your answers, where appropriate:
- Use flow charts or diagrams
- Give named examples
- Define synergism, antagonism and indifference in anti-bacterial chemotherapy with specific case examples (20%). Write an essay on the role of whole-cell phenotypic evaluation methods in antibiotic discovery with special reference to HT-SPOTi (80%).
- Give details of how a named pro-drug targets endogenous metabolism in bacteria (20%). Discuss how antibiotic resistant strains develop in bacteria, and discuss the significance of the permeability barrier and active drug efflux in this process (80%).
- Comment on antimicrobial drug resistance as a global health challenge (20%). Write an essay on validating arylamine N-acetyl transferase (NAT) as a novel therapeutic target in Mycobacterium tuberculosis (80%).
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