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Give details of how a named pro-drug targets endogenous metabolism in bacteria (20%). Discuss how antibiotic resistant strains develop in bacteria, and discuss the significance of the permeability barrier and active drug efflux in this process

You must choose ONLY ONEquestion out of THREE

 Each question is worth 100 marks.

 In your answers, where appropriate:

  • Use flow charts or diagrams
  • Give named examples
  1. Define synergism, antagonism and indifference in anti-bacterial chemotherapy with specific case examples (20%). Write an essay on the role of whole-cell phenotypic evaluation methods in antibiotic discovery with special reference to HT-SPOTi (80%).
  2. Give details of how a named pro-drug targets endogenous metabolism in bacteria (20%). Discuss how antibiotic resistant strains develop in bacteria, and discuss the significance of the permeability barrier and active drug efflux in this process (80%).
  3. Comment on antimicrobial drug resistance as a global health challenge (20%). Write an essay on validating arylamine N-acetyl transferase (NAT) as a novel therapeutic target in Mycobacterium tuberculosis (80%).

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