Define synergism, antagonism and indifference in anti-bacterial chemotherapy with specific case examples

You must choose ONLY ONEquestion out of THREE

 Each question is worth 100 marks.

 In your answers, where appropriate:

• Use flow charts or diagrams
• Give named examples

1. Define synergism, antagonism and indifference in anti-bacterial chemotherapy with specific case examples (20%). Write an essay on the role of whole-cell phenotypic evaluation methods in antibiotic discovery with special reference to HT-SPOTi (80%).
2. Give details of how a named pro-drug targets endogenous metabolism in bacteria (20%). Discuss how antibiotic resistant strains develop in bacteria, and discuss the significance of the permeability barrier and active drug efflux in this process (80%).
3. Comment on antimicrobial drug resistance as a global health challenge (20%). Write an essay on validating arylamine N-acetyl transferase (NAT) as a novel therapeutic target in Mycobacterium tuberculosis (80%).